Letairis (ambrisentan) logo
For HCPs

Letairis (ambrisentan) is a prescription medicine to treat pulmonary arterial hypertension (PAH) (WHO Group 1) in patients with WHO Class II or III symptoms. PAH is high blood pressure in the arteries of the lungs.

Last updated: May, 2017

A community for PAH patients

Letairis More to My Story is an online resource that provides empowering information to educate and support PAH patients. Designed for PAH patients and their loved ones, you’ll find information about Letairis treatment, inspiring patient stories, recipes, exercise tips and more. You and your friends and family are invited to join us today.
Join our online community now to receive helpful information delivered to your email and gain access to a complete library of tips and tools

Welcome to the

Newsletter


In this issue:

Ambassador’s Corner

Michelle, our More to My Story Ambassador, talks about her PAH support system

Spotlight

Who’s in your corner? Find a PAH support group

Recipe Roundup

Dilled pasta salad with spring vegetables

If you’re not already registered with More to My Story, sign up now to receive email updates when new issues of the newsletter are available online.

What is Letairis?

Letairis is a prescription medicine used to treat pulmonary arterial hypertension (PAH), which is high blood pressure in the arteries of the lungs.

  • Letairis can improve your ability to exercise and it can help slow down the worsening of your physical condition and symptoms
  • When taken with tadalafil, Letairis is used to reduce the risks of your disease progressing and hospitalization due to worsening PAH, and to improve your ability to exercise
 
Spotlight

Who’s in your corner?
Find a support group

Living with PAH can be difficult. But having people around you who understand what you’re going through can make things a bit easier. While your friends and family are probably your greatest source of support, PAH-focused support groups can help, too. Consider these reasons for joining a PAH support group near you:

  • You’ll be with people who understand. People in support groups understand the challenges you face living with PAH. You can learn what’s worked for them and find inspiration in shared stories.
  • You’ll learn new things. Support groups offer you a great way to stay current with the latest information on PAH.
  • You’ll have a voice. PAH support groups are at the forefront of advocating for additional research in hopes of someday finding a cure.

Remember, you’re not alone. There are other people living with PAH waiting to offer you support.

 




“When I was first diagnosed with PAH, I attended a support group. It’s important to connect with people like you, because you learn things. Now I’m a support group leader because it’s important to give back to my community.”

Speak out

Are you in a PAH support group?


Michelle, our More to My Story Ambassador, talks in this month’s video diary about how important her support network of family and friends is to her.

 
We’d like to know: are you in a support group for people with PAH? Tell us by choosing from the list below.




Recipe Roundup

Ingredients

For the dressing:

  • 1/4 cup olive oil
  • 2 tablespoons lemon juice
  • 2 tablespoons rice or white wine vinegar
  • 2 teaspoons dill weed
  • Cracked black pepper, to taste

For the salad:

  • 3 cups uncooked whole-grain shell pasta, medium-sized
  • 8 asparagus spears, cut into 1/2-inch pieces
  • 1 cup halved cherry tomatoes
  • 1 cup sliced green peppers
  • 1/2 cup chopped green (spring) onions
 
Recipe
Roundup

Dilled pasta salad with spring vegetables*

Nothing says spring quite like a bountiful salad full of fresh seasonal veggies. This recipe ditches the salt and replaces it with vinegar and dill for a bright, refreshing flavor. And the best part is that one serving contains a meager 11 mg of sodium.

Directions

To make the dressing, in a small bowl add the olive oil, lemon juice, vinegar, dill weed, and black pepper. Whisk to mix evenly. Set aside.

To make the salad, fill a large pot 3/4 full with water and bring to a boil. Add the pasta and cook until tender (al dente), 10 to 12 minutes, or according to the package directions. Drain the pasta thoroughly and rinse under cold water.

In a small saucepan, cover the asparagus with water. Bring to a boil and cook only until tender-crisp, about 3 to 5 minutes. Drain and rinse under cold water.

In a large bowl, add the pasta, asparagus, tomatoes, green peppers, onions and dressing.

Toss to mix evenly.

Cover and refrigerate. Serve chilled.

Is Letairis right for you?


Letairis + tadalafil may help improve your ability to exercise, reduce the risk of your PAH getting worse, and reduce your risk of hospitalizations due to PAH. Get more details about Letairis.


Ready to talk to your doctor about Letairis?

Find out if Letairis may be appropriate for you. Use this Doctor Discussion Guide to start the conversation with your PAH Specialist.

Important Safety Information and Indication

What is the most important information I should know about Letairis?

Letairis can cause serious birth defects if taken during pregnancy.

  • Females must not be pregnant when they start taking Letairis or become pregnant while taking Letairis
  • Females who are able to get pregnant must have a negative pregnancy test before starting Letairis, every month while taking Letairis, and 1 month after stopping Letairis. Your doctor will decide when to do the tests, and order the tests for you depending on your menstrual cycle
    • Females who are able to get pregnant are females who have entered puberty (even if they have not started their period), and have a uterus, and have not gone through menopause (menopause means that you have not had a period for at least 12 months for natural reasons, or that you have had your ovaries removed)

Females who are able to get pregnant must use two acceptable forms of birth control while taking Letairis and for 1 month after stopping Letairis because the medicine may still be in the body. See the Letairis Medication Guide for acceptable birth control options.

  • If you have had a tubal sterilization or have an IUD (intrauterine device) or progesterone implant, these methods can be used alone and no other form of birth control is needed
  • Talk with your doctor to find out about options for acceptable forms of birth control that you may use to prevent pregnancy during treatment with Letairis
  • If you decide that you want to change the form of birth control, talk with your doctor to be sure that you choose another acceptable form of birth control
  • Do not have unprotected sex. Talk to your doctor or pharmacist right away if you have unprotected sex or if you think your birth control has failed. Your doctor may tell you to use emergency birth control
  • Tell your doctor right away if you miss a menstrual period or think you may be pregnant

If you are the parent or caregiver of a female child who started taking Letairis before reaching puberty, you should check your child regularly to see if she is developing signs of puberty. Tell your doctor right away if you notice that she is developing breast buds or any pubic hair. Your child may reach puberty before having her first menstrual period.

Females can only receive Letairis through a restricted program called the Letairis Risk Evaluation and Mitigation (REMS) program. If you are a female who can get pregnant, you must talk to your doctor, understand the benefits and risks of Letairis, and agree to all of the instructions in the Letairis REMS program.

Who should not take Letairis?

Do not take Letairis if:

  • You are pregnant, plan to become pregnant, or become pregnant while taking Letairis. Letairis can cause serious birth defects. (See "What is the most important information I should know about Letairis?")
  • You have Idiopathic Pulmonary Fibrosis (IPF)

What should I avoid while taking Letairis?

  • Do not get pregnant. If you miss a menstrual period, or think you might be pregnant, call your doctor right away
  • Do not breastfeed. It is not known if Letairis passes into your breast milk

What are the other possible side effects of Letairis?

Serious side effects of Letairis can include:

  • Swelling all over the body (fluid retention) can happen within weeks after starting Letairis. Tell your doctor right away if you have any unusual weight gain, tiredness, or trouble breathing while taking Letairis. These may be symptoms of a serious health problem. You may need to be treated with medicine or need to go to the hospital
  • Decreased sperm counts have happened in some men taking a medicine that is like Letairis, which may affect your ability to father a child. Tell your doctor if being able to have children is important to you
  • Low red blood cell levels (anemia) can happen during the first weeks after starting Letairis. If this happens, you may need a blood transfusion. Your doctor will do blood tests to check your red blood cells before starting Letairis. Your doctor may also do these tests while you are taking Letairis

The most common side effects of Letairis are swelling of hands, legs, ankles and feet (peripheral edema), stuffy nose (nasal congestion), inflamed nasal passages (sinusitis), hot flashes or getting red in the face (flushing). Tell your doctor if you have any side effect that bothers you or does not go away.

The most common side effects of Letairis when taken with tadalafil are swelling of hands, legs, ankles and feet (peripheral edema), headache, stuffy nose (nasal congestion), cough, low red blood cell levels (anemia), indigestion (dyspepsia) or upper respiratory tract infection (bronchitis).

Some medicines that are like Letairis can cause liver problems. Tell your doctor if you get any of these symptoms while taking Letairis: loss of appetite, nausea or vomiting, fever, achiness, generally do not feel well, pain in the upper right stomach (abdominal) area, yellowing of your skin or the whites of your eyes, dark urine, itching.

What should I tell my doctor before taking Letairis?

  • All your medical conditions. Be sure to tell your doctor if you have a low red blood cell level (anemia) or liver problems
  • All the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. Letairis and other medicines may affect each other causing side effects. Do not start any new medicines until you check with your doctor
  • Especially tell your doctor if you take cyclosporine (Gengraf, Neoral, Sandimmune). Your doctor may need to change your dose of Letairis

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Letairis (ambrisentan) is a prescription medicine to treat pulmonary arterial hypertension (PAH) (WHO Group 1) in patients with WHO Class II or III symptoms. PAH is high blood pressure in the arteries of the lungs.

Please see full Prescribing Information, including Medication Guide, with important warnings.