Letairis® (ambrisentan) logo
For HCPs

Letairis (ambrisentan) is a prescription medicine used to treat pulmonary arterial hypertension (PAH), which is high blood pressure in the arteries of the lungs.

LEAP offers support that may help you afford
your medication

No matter what kind of insurance you have, LEAP is here to help make sure you receive your LETAIRIS on time

Depending on your insurance and eligibility for support resources, LEAP may be able to help you locate resources to lower your out-of-pocket costs.


Confused about your insurance benefits? LEAP offers educational information on insurance coverage. Learn some basics here.

  • Understand your insurance benefits

    It is important to know that your prescription coverage has two payment parts—what your insurance pays (your drug benefit) and what you pay (your co-pay/coinsurance or out-of-pocket costs). If you need help understanding your insurance benefits for Letairis, please call LEAP.

    If you need help paying for your out-of-pocket costs, LEAP may be able to help you find financial support. If you are uninsured or underinsured, there may be programs available to help cover some or all of your treatment costs. For more information contact LEAP at 1-866-664-5327.

  • Eligible patients who have commercial insurance pay just $5 per month for Letairis.

    The Letairis Co-Pay Coupon Program can help with your out-of-pocket costs. If you are eligible, you may pay no more than a $5 co-pay per prescription fill. This program provides co-pay assistance of up to $15,000 per year.* Click here for Terms and Conditions.

    Call LEAP today at 1-866-664-5327 to see if you are eligible for this program.

    If there is a change in your commercial insurance, LEAP can help you through the transition. Learn how here.

    Terms and Conditions

    The Gilead Letairis Co-pay Coupon Program ("Coupon") can be used only by eligible residents of the U.S., Puerto Rico, or U.S. Territories via Certified Pharmacies who dispense Letairis. Product must originate in the U.S. or Puerto Rico, or U.S. Territories. You must be 18 years or older to use the Coupon for yourself or a minor.

    The Coupon is not insurance and is not intended to substitute for insurance.

    THE COUPON IS VALID ONLY FOR PATIENTS WITH COMMERCIAL INSURANCE AND IS NOT VALID FOR PRESCRIPTIONS THAT ARE ELIGIBLE TO BE REIMBURSED IN WHOLE OR IN PART BY MEDICARE, A MEDICARE PART D PLAN, MEDICAID, TRICARE, VA, DOD, PUERTO RICO GOVERNMENT HEALTH INSURANCE PLAN ("HEALTHCARE REFORM"), OR ANY OTHER FEDERAL OR STATE-FUNDED HEALTHCARE BENEFIT PROGRAM (COLLECTIVELY, "GOVERNMENT PROGRAMS"); OR BY COMMERCIAL PLANS OR OTHER HEALTH OR PHARMACY BENEFIT PROGRAMS THAT REIMBURSE FOR THE ENTIRE COST OF PRESCRIPTION DRUGS.

    Medicare Part D Enrollees who are in the prescription drug coverage gap (the "donut hole") are not eligible for the Coupon. Patients who begin receiving prescription benefits from Government Programs at any time will no longer be eligible to use the Coupon. Void where prohibited by law, taxed, or restricted.

    Patient, pharmacist, and prescriber agree not to seek reimbursement for all or any part of the benefit received by the patient through the offer. Both patient and pharmacist are each individually responsible for reporting receipts of Coupon benefit to any insurer, health plan, or other third party who pays for, or reimburses, any part of the prescription filled using the Coupon, as required. It is illegal to sell, purchase, trade, or counterfeit, or offer to sell, purchase, trade, or counterfeit the Coupon.

    Certain information pertaining to use of the Coupon will be shared with Gilead, the sponsor of the Coupon, and its affiliates. The information disclosed will include the date the prescription is filled, the number of pills or product dispensed by the pharmacist, and the amount of the co-pay that will be paid for by using the Coupon.

    *Patients are not eligible if they are enrolled in a government healthcare prescription drug program such as Medicare Part D or Medicaid. This includes patients who are in the Medicare Part D coverage gap known as the "donut hole."

  • If you have government insurance such as Medicare or Medicaid, your benefits can be difficult to understand. Benefits may change every year, but the good news is that LEAP can help. Your LEAP Case Specialist can help you determine other sources of funding that may be available to you. Call LEAP at 1-866-664-5327 to learn more about your benefits and eligibility for financial support.

    Patients on Medicare may fall into a coverage gap, also known as the “donut hole.” During this time, your out-of-pocket costs may be higher. The good news is that costs will lower once you’re out of this gap. Your LEAP Case Specialist can help you understand your out-of-pocket costs for each month of the year on Letairis, call 1-866-664-5327 today.

    If your Medicare Part D coverage is not enough to cover your Letairis costs, LEAP can help find an outside source to help cover your out-of-pocket costs, including co-pays, coinsurance, and deductibles. These resources are independent, nonprofit organizations that have their own eligibility criteria and application process.

    To better understand your Medicare Part D prescription coverage, visit the Medicare website here.

  • If you do not have insurance or your insurance does not cover Letairis costs, LEAP can offer guidance and may be able to help identify financial support for Letairis. LEAP can determine if your financial situation qualifies you to receive your medication free of charge through the Letairis Patient Assistance Program.

    LEAP can also offer guidance and may be able to help identify financial support resources outside of your insurance. These third-party resources may be able to help with your out-of-pocket costs, including co-pays, coinsurance, and deductibles. They are independent, nonprofit organizations that have their own eligibility criteria and application process.

    If you are struggling to cover your out-of-pocket costs or have no insurance at all, call 1-866-664-5327 today to explore possible support options.


LEAP can also help if you have changes to your insurance

If you encounter changes in your coverage benefits, contact LEAP right away to help you through the transition. LEAP can:

  • Coordinate the requirements for your new coverage, including Prior Authorization
  • Help avoid delays in your Letairis shipment

You can rely on LEAP to help you during these times and to help answer any of the following questions as well:


To learn more about how LEAP may help, call  
to speak with a dedicated Case Specialist

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More to My Story provides education and resources about topics that may interest you. Designed for patients taking Letairis, you'll find information about starting Letairis, recipes, exercise tips, empowering patient stories, and more sent right to your inbox. Join us today.

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Learn more about getting started
on Letairis

Find helpful information in this Patient Starter Brochure

Download the
brochure
Find out how to get started on Letairis

Ask your
doctor
about Letairis

Prepare for your next doctor appointment with a discussion guide

View the guide
Ask your doctor about Letairis

Learn more
about PAH

See what causes PAH, how it's diagnosed, and more

Get the details
Learn more about PAH
Find out how to get started on Letairis

Learn more about getting started
on Letairis

Find helpful information in this Patient Starter Brochure

Download the
brochure
Ask your doctor about letairis

Ask your
doctor
about Letairis

Prepare for your next doctor appointment with a discussion guide

View the guide
Learn more about PAH

Learn more
about PAH

See what causes PAH, how it's diagnosed, and more

Get the details

Important Safety Information
and Indication

What is the most important information I should know about Letairis?

Letairis can cause serious birth defects if taken during pregnancy.

  • Females must not be pregnant when they start taking Letairis or become pregnant while taking Letairis
  • Females who are able to get pregnant must have a negative pregnancy test before starting Letairis, every month while taking Letairis, and 1 month after stopping Letairis. Your doctor will decide when to do the tests, and order the tests for you depending on your menstrual cycle
    • Females who are able to get pregnant are females who have entered puberty (even if they have not started their period), and have a uterus, and have not gone through menopause (menopause means that you have not had a period for at least 12 months for natural reasons, or that you have had your ovaries removed)

Females who are able to get pregnant must use two acceptable forms of birth control while taking Letairis and for 1 month after stopping Letairis because the medicine may still be in the body. See the Letairis Medication Guide for acceptable birth control options.

  • If you have had a tubal sterilization or have an IUD (intrauterine device) or progesterone implant, these methods can be used alone and no other form of birth control is needed
  • Talk with your doctor to find out about options for acceptable forms of birth control that you may use to prevent pregnancy during treatment with Letairis
  • If you decide that you want to change the form of birth control, talk with your doctor to be sure that you choose another acceptable form of birth control
  • Do not have unprotected sex. Talk to your doctor or pharmacist right away if you have unprotected sex or if you think your birth control has failed. Your doctor may tell you to use emergency birth control
  • Tell your doctor right away if you miss a menstrual period or think you may be pregnant

If you are the parent or caregiver of a female child who started taking Letairis before reaching puberty, you should check your child regularly to see if she is developing signs of puberty. Tell your doctor right away if you notice that she is developing breast buds or any pubic hair. Your child may reach puberty before having her first menstrual period.

Females can only receive Letairis through a restricted program called the Letairis Risk Evaluation and Mitigation (REMS) program. If you are a female who can get pregnant, you must talk to your doctor, understand the benefits and risks of Letairis, and agree to all of the instructions in the Letairis REMS program.

Who should not take Letairis?

Do not take Letairis if:

  • You are pregnant, plan to become pregnant, or become pregnant while taking Letairis. Letairis can cause serious birth defects. (See "What is the most important information I should know about Letairis?")
  • You have Idiopathic Pulmonary Fibrosis (IPF)

What should I avoid while taking Letairis?

  • Do not get pregnant. If you miss a menstrual period, or think you might be pregnant, call your doctor right away
  • Do not breastfeed. It is not known if Letairis passes into your breast milk

What are the other possible side effects of Letairis?

Serious side effects of Letairis can include:

  • Swelling all over the body (fluid retention) can happen within weeks after starting Letairis. Tell your doctor right away if you have any unusual weight gain, tiredness, or trouble breathing while taking Letairis. These may be symptoms of a serious health problem. You may need to be treated with medicine or need to go to the hospital
  • Decreased sperm counts have happened in some men taking a medicine that is like Letairis, which may affect your ability to father a child. Tell your doctor if being able to have children is important to you
  • Low red blood cell levels (anemia) can happen during the first weeks after starting Letairis. If this happens, you may need a blood transfusion. Your doctor will do blood tests to check your red blood cells before starting Letairis. Your doctor may also do these tests while you are taking Letairis

The most common side effects of Letairis are swelling of hands, legs, ankles and feet (peripheral edema), stuffy nose (nasal congestion), inflamed nasal passages (sinusitis), hot flashes or getting red in the face (flushing). Tell your doctor if you have any side effect that bothers you or does not go away.

The most common side effects of Letairis when taken with tadalafil are swelling of hands, legs, ankles and feet (peripheral edema), headache, stuffy nose (nasal congestion), cough, low red blood cell levels (anemia), indigestion (dyspepsia) or upper respiratory tract infection (bronchitis).

Some medicines that are like Letairis can cause liver problems. Tell your doctor if you get any of these symptoms while taking Letairis: loss of appetite, nausea or vomiting, fever, achiness, generally do not feel well, pain in the upper right stomach (abdominal) area, yellowing of your skin or the whites of your eyes, dark urine, itching.

What should I tell my doctor before taking Letairis?

  • All your medical conditions. Be sure to tell your doctor if you have a low red blood cell level (anemia) or liver problems
  • All the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. Letairis and other medicines may affect each other, causing side effects. Do not start any new medicines until you check with your doctor
  • Especially tell your doctor if you take cyclosporine (Gengraf, Neoral, Sandimmune). Your doctor may need to change your dose of Letairis

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

What is Letairis?

Letairis is a prescription medicine used to treat pulmonary arterial hypertension (PAH), which is high blood pressure in the arteries of the lungs.

  • Letairis can improve your ability to exercise and it can help slow down the worsening of your physical condition and symptoms
  • When taken with tadalafil, Letairis is used to reduce the risks of your disease progressing and hospitalization due to worsening PAH, and to improve your ability to exercise

Please see full Prescribing Information, including Medication Guide, with important warnings.