Letairis® (ambrisentan) logo
For HCPs

Letairis (ambrisentan) is a prescription medicine used to treat pulmonary arterial hypertension (PAH), which is high blood pressure in the arteries of the lungs.

Questions about medication costs?

Turn to LEAP to help understand your out-of-pocket costs

LEAP is ready to help whether you have commercial insurance (for example, from your employer), government-provided coverage (such as Medicare Part D), or if you are uninsured.

Now that generic versions of Letairis are available, it's important to know that, in some cases, your out-of-pocket costs for branded Letairis may be less than for generic ambrisentan. LEAP can help explain how your out-of-pocket costs may be affected by a switch from branded Letairis to a generic and identify potential resources to help. LEAP is available no matter what type of insurance you have or if you are uninsured or underinsured.


Confused about your insurance benefits? LEAP offers educational information on insurance coverage. Learn some basics here.

  • Understand your insurance benefits

    It is important to know that your prescription coverage has two payment parts—what your insurance pays (your drug benefit) and what you pay (your co-pay/coinsurance or out-of-pocket costs). If you need help understanding your insurance benefits for Letairis, please call LEAP.

    If you need help paying for your out-of-pocket costs, LEAP may be able to help you find financial support. If you are uninsured or underinsured, there may be programs available to help cover some or all of your treatment costs. For more information contact LEAP at 1-866-664-5327.

  • Patients who have commercial insurance may pay as little as $5 per month for Letairis. Eligible patients are automatically enrolled when they are prescribed branded Letairis.

    The Letairis Co-Pay Coupon Program can help with your out-of-pocket costs. If you are eligible, you may pay no more than a $5 co-pay per prescription fill. This program provides co-pay assistance of up to $20,000 per year. Click here for Terms and Conditions.

    Call LEAP today at 1-866-664-5327 to see if you are eligible for this program.

    Terms and Conditions

    The Letairis Co-pay Coupon Program ("Coupon") can be used only by eligible residents of the U.S., Puerto Rico, or U.S. Territories via Certified Pharmacies who dispense Letairis. Product must originate in the U.S. or Puerto Rico, or U.S. Territories. You must be 18 years or older to use the Coupon for yourself or a minor.

    The Coupon is not insurance and is not intended to substitute for insurance.

    THE COUPON IS VALID ONLY FOR PATIENTS WITH COMMERCIAL INSURANCE AND IS NOT VALID FOR PRESCRIPTIONS THAT ARE ELIGIBLE TO BE REIMBURSED IN WHOLE OR IN PART BY MEDICARE, A MEDICARE PART D PLAN, MEDICAID, TRICARE, VA, DOD, PUERTO RICO GOVERNMENT HEALTH INSURANCE PLAN, OR ANY OTHER FEDERAL OR STATE-FUNDED HEALTHCARE BENEFIT PROGRAM (COLLECTIVELY, "GOVERNMENT PROGRAMS"); OR BY COMMERCIAL PLANS OR OTHER HEALTH OR PHARMACY BENEFIT PROGRAMS THAT REIMBURSE FOR THE ENTIRE COST OF PRESCRIPTION DRUGS.

    Medicare Part D Enrollees who are in the prescription drug coverage gap (the "donut hole") are not eligible for the Coupon. Patients who begin receiving prescription benefits from Government Programs at any time will no longer be eligible to use the Coupon. Void where prohibited by law, taxed, or restricted.

    Patient, pharmacist, and prescriber agree not to seek reimbursement for all or any part of the benefit received by the patient through the offer. Both patient and pharmacist are each individually responsible for reporting receipts of Coupon benefit to any insurer, health plan, or other third party who pays for, or reimburses, any part of the prescription filled using the Coupon, as required. It is illegal to sell, purchase, trade, or counterfeit, or offer to sell, purchase, trade, or counterfeit the Coupon.

    Certain information pertaining to use of the Coupon will be shared with Gilead, the sponsor of the Coupon, and its affiliates. The information disclosed will include the date the prescription is filled, the number of pills or product dispensed by the pharmacist, and the amount of the co-pay that will be paid for by using the Coupon.

  • LEAP can help you better understand your out-of-pocket medication costs through an investigation of your benefits and may be able to help identify resources for financial support.

    • LEAP can help you understand how your out-of-pocket costs may vary from month to month, depending on which phase of Medicare Part D coverage you are in
    • Patients taking Letairis may fall into the coverage gap, also known as the "donut hole," early in the year. During this time, your out-of-pocket costs will likely be higher than at other times of the year. Because of cost sharing required by branded drug manufacturers during the coverage gap, branded Letairis may cost less out of pocket than a generic*

    *Assumes Part D Plan utilization of the standard Medicare Part D benefit design. Based on internal forecasts of generic pricing relative to Letairis.

    If your Medicare Part D coverage is not enough to cover your Letairis costs, LEAP can assist in identifying an outside source to help cover your out-of-pocket costs, including co-pays, coinsurance, and deductibles. These resources are independent, nonprofit organizations that have their own eligibility criteria and application process.

    To better understand your Medicare Part D prescription coverage, visit the Medicare website here.

  • If you do not have insurance or your insurance does not cover Letairis costs, LEAP can offer guidance and may be able to help identify financial support for Letairis. LEAP can determine if your financial situation qualifies you to receive your medication free of charge through the Letairis Patient Assistance Program.

    LEAP can also offer guidance and may be able to help identify financial support resources outside of your insurance. These third-party resources may be able to help with your out-of-pocket costs, including co-pays, coinsurance, and deductibles. They are independent, nonprofit organizations that have their own eligibility criteria and application process.

    If you are struggling to cover your out-of-pocket costs or have no insurance at all, call 1-866-664-5327 today to explore possible support options.


LEAP can also help if you have changes to your insurance

If you encounter changes in your coverage benefits, contact LEAP right away to help you through the transition. LEAP can:

  • Coordinate the requirements for your new coverage, including Prior Authorization
  • Help avoid delays in your Letairis shipment

Contact LEAP at 1-866-664-5327.

You can rely on LEAP to help you during these times and to help answer any of the following questions as well:


To learn more about how LEAP may help, call  

Did you know? More than 40,000 patients have been prescribed Letairis since FDA approval in 2007. Get the details here.

TAP FOR IMPORTANT SAFETY INFORMATION INCLUDING AN IMPORTANT WARNING ON SERIOUS BIRTH DEFECTS IF TAKEN DURING PREGNANCY.
TAP FOR IMPORTANT SAFETY INFORMATION INCLUDING AN IMPORTANT WARNING ON SERIOUS BIRTH DEFECTS IF TAKEN DURING PREGNANCY.